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Efficacy of Hypoxytherapy in the treatment of different diseases in patients in the prophylaxic clinic "Tamara", Murmansk, Russia.
[Kononenko et al, 1997]

Clinical Results of IHT Treatment of Various Diseases
N Pathology All cases From 10 to 15 IHT sessions From 16 to 25 IHT sessions
      In all Inprove-
ments
Without
changes
In all Inprove-
ments
Without
changes
1 Ischaemic Heart Disease (IHD) 88 55 52 3 33 32 1
2 IHD + Hypertension 6 4 3 1 2 2 -
3 Hypertension 116 77 72 5 39 31 2
4 Neurocirculatory asthenia 46 37 35 2 9 9 -
5 Bronchial asthma 10 4 4 - 6 6 -
6 Chronic bronchitis 59 43 41 2 16 16 -
7 Ulcerative disease of stomach,
duodenum
42 28 27 1 14 14 -
8 Liver and Pancreatic diseases 31 25 23 2 6 6 -
9 Diabetes mellitus 3 3 3 - - - -
10 Toxaemia of pregnancy 2 - - - 2 2 -
11 Anaemia 1 1 1 - - - -
12 Diseases of locomotion 217 161 150 11 56 55 1
13 Diseases of urinary tract 20 13 13 - 7 7 -
14 Others 46 34 32 2 12 11 1
  In all 687 485 456 29 202 197 5
  %   100 94   100 97.5 2.5

TABLE 1.

Clinical Applications of IHT

Statistically significant data indicates that after a course of IHT treatment, the following effects become apparent:
• Decrease in fatigue
• Decrease in head, joint, and chest pains
• Increase in working capacity

The number of complaints in % to the number of all patients
Sanatorium "Orbita",
Kursk nuclear power
station (4180 cases)
[Agadzhanian et al, 1997].


Before IHT
After IHT

Headache 85
8
Fatigue 80
15
Decrease in working capacity 77
5
Unpleasant sensations 56
6
Irritation 89
18
Insomnia 64
9
Breathlessness 25
8
Suffocation fits 4
1
Arrhythmia 58
20
Chest pain 57
19
Skin eruption 8
5
Jointache 34
16
Cough 12
3
 
0 10 20 30 40 50 60 70 80 90%

TABLE 2.

The results of IHT treatment ('Mountain Air" treatment) in the prophylaxic clinic "Sanatorium Tamara" Murmansk, Russia. (Kononenko et al, 1997)

The Number Of Complaints In % To Overall Number Of Patients
N Complaints Before IHT treatment After IHT treatment p
1 Headache 39.2 ± 1.5 7.1 ± 0.8 <0.001
2 Chest pains 36.3 ± 1.5 4.4 ± 0.6 <0.001
3 Breathlessness 24.7 ± 1.3 13.7 ± 1.0 <0.001
4 Suffocation fits 4.1 ± 0.6 0.7 ± 0.3 <0.001
5 Cough 20.1 ± 1.2 4.6 ± 0.6 <0.001
6 Insomnia 33.3 ± 1.4 3.3 ± 0.5 <0.001
7 Irritation 37.5 ± 1.5 6.6 ± 0.8 <0.001
8 Fatigue 72.7 ± 1.4 17.2 ± 1.1 <0.001
9 Impaired work capacity 58.0 ± 1.5 5.7 ± 0.7 <0.001
10 Unpleasant sensations 70.8 ± 1.4 7.8 ± 0.8 <0.001
11 Joint aches 37.0 ± 1.5 15.4 ± 1.1 <0.001
12 Depressed mood 37.6 ± 1.5 9.3 ± 0.9 <0.001

Alteration in the respiratory system and oxygen supply and mental working capacity in children with cerebral palsy.

Research Study conducted by AZ Kolchinskaya et al. "Rainbow" Children's Rehabilitation Centre Nalchik, Russian Federation.
IHT group (n=78) and control group(n=50).

Before IHT
After IHT

Parameters of external respiration



Parameters of external respiration



TABLE 4.

Reduction in mortality from coronary heart disease in men residing at high altitude. The New England Journal of Medicine 1977

Study looking at the mortality from coronary heart disease in over 6 million subjects in 5 sets of countries, grouped at altitude in 305 m increments. The study showed a decline in mortality from the lowest to the highest altitude for males but not females. Read the abstract (PDF)

Effects of IHT on blood lipid concentrations in male coronary heart disease patients. 2002

Total Cholesterol decreased by 7% on completion of a course of IHT. Improving to 9% after 3 months. Remained at that level at 6 months.

The ratio of HDL (High Density Lipoprotein) and LDL (Low Density Lipoprotein) improved. HDL increased to 12% at 3 months and remained high at month 6. LDL levels declined but were most apparent at month 3 (13%) and month 6 (11%)

CA (Coefficient of artherogenity) declined by 26% after IHT and 37% by month 3. CA is thought to be an integral measure of plasma atherogenic potential. Read the abstract (PDF)

Anthihypertensive efficacy of adaption to Intermittent Hypoxia Vs Beta-Blocker and NO donor therapy: Role of nitric Oxide.
Institute of General Pathology and Pathophysiology, Moscow, Russia

The study objective was to compare drug and non-drug stimulation of nitric oxide synthesis. The study was conducted on Rats for 40 days. Group 1 were subjected to IHT. Group 2 took a nitric oxide donor every 4th day, Dinitrosyl Iron complex (DINC 170 ug/kg). Group 3 took the Beta-Blocker Nebrivlol (1.25mg/kg). The IHT and Beta-Blocker group showed a decrease in blood pressure. The IHT group appeared to be more efficient antihypertensive and vasoprotective means than the other two methods. The advantages of IHT can be due to the following mechanisms:

IHT both stimulates nitric oxide synthesis and induces expression of the gene that controls nitric oxide production.
IHT results in the formation of nitric oxide stores in the vascular wall, which may serve as an additional source of free nitric oxide.
IHT activates antioxidant enzymes and thereby prevents detrimental effects of free radicals on nitric oxide synthesis.
IHT possesses additional antihypertensive mechanisms such as stimulation of sodium and water secretion, decreasing vascular adrenoreactivity, etc.
Read the abstract (PDF)

Selection of relevant scientific papers:

Reduction in mortality from coronary heart disease in men residing at high altitude. The New England Journal of Medicine 1977


733Kb

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Effects of IHT on blood lipid concentrations in male coronary heart disease patients. 2002

110Kb
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Anthihypertensive efficacy of adaption to Intermittent Hypoxia Vs Beta-Blocker and NO donor therapy: Role of nitric Oxide.

75Kb

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Low-oxygen switch for cells discovered which could help in the recovery from stroke and heart attack. Australia, 2002.

65Kb

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Hypoxia stimulates transport in insulin resistant skeletal muscle

33Kb

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Article - Hypoxia upregs glucose transport through increase GLUT1

494Kb

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Diabetics and non-diab exposure to hypoxia

494Kb

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Diabetics and non-diab exposure to hypoxia

262Kb

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Effect of IHT and Exercise on glucose tolerance and muscle GLUT4 in rats

276Kb

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